The views of science, business, and farmers on the operation of organic farming and GMOs in plants and animals are often extreme. Shots are pros and cons of co-existence of such systems of production. The study is based on knowledge that could come close positions of the parties in the discussion and used for this purpose the species Solanum tuberosum. Due to the vegetative mode of propagation of potato, the coexistence of organic, conventional and GMO use in cultivation systems is possible. Provided that there is compliance with the principles of coexistence and preservation of food and feed safety.