Conducting plant protection operations belongs to the most unhealthy jobs from among a range of agricultural activities. A direct contact with chemical substances negatively influences the functioning of the digestive and respiratory systems. In extreme cases it results in poisoning and even death of the person who had a direct contact with the chemical. The objective of the article was to evaluate the application of safety rules when dealing with pesticides both when preparing a liquid form of the active substance and while spraying plants and conditioning seeds for sowing. The research was conducted by interviewing people directly on their farms. Based on the collected data connected with the application of pesticides, the operations were identified where a direct contact of the chemical substance with the farmer’s skin or an internal organ was observed. Health side-effects were also presented in dealing with pesticides as a result of neglecting the application of personal protection measures. It was also described how to store plant protection products on farms and which protection measures should be taken to avoid uncontrolled contact with the pesticide while applying it. It was reported that about 40% of farmers do not follow the safety rules while applying or preparing chemical substances for usage. Consequently, it results in the irritation of skin, eyes and the whole respiratory system, and in some cases to nausea and headaches.